If you find that your "in" box seems to be always overflowing with clutter that you "out" box it's not an isolated issue. The clutter in your office is a problem that virtually every homeowner will face at some point during their life.
The problem may be compounded if you have multiple family members who use the home office, or if you happen to work from home. You can visit officereno.sg/office-renovation/ for home office renovation.
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Divide and conquer
Depending on how much clutter has cropped up, splitting the job up into smaller parts can be an effective way to deal with problems. Often when you think about tackling a clean-up and organization job, you get overwhelmed by the big picture. The bigger the mess, the more likely this is to happen.
Designate a spot for everything
Every item in your home office should have its own "home." You can create any system you like, as long as it works for you, and as long as it doesn't lend itself to accumulating even more clutter later on.
A good rule of thumb is to keep the things that you use most often in the closest, most easily accessible location. For many homeowners, these things are pens, pencils, paper clips, scissors, etc.
You may also want to consider expanding your workspace/home office. Adding built-in, customized shelving and other storage solutions can help you get organized and stay organized.